63 ČTVRTEK / 2. listopadu 2023 / 9.30–11.00 hod. / SÁL A + B NEFARMAKOLOGICKÉ POSTUPY VE ZVLÁDÁNÍ REZISTENTNÍCH STAVŮ Sympozium Společnosti pro biologickou psychiatrii Předsedá: Klára Látalová Transkraniální Stimulace Stejnosměrným Proudem (Tdcs) U Post‑Akutních Následků SARS‑COV-2 Klírová M., Biačková N., Laskov O., Adamová A. NUDZ, Klecany 3. LF UK, Praha Transcranial direct current stimulation (TDCS) in post-acute neuropsychiatric sequelae of SARS-COV-2 Background: There is a significant lack of effective treatment strategies for post-acute sequelae of SARS-Cov-2 (PASC). Neuropsychiatric (NP) symptoms, including emotional and cognitive dysregulation, are among the most common manifestations of PASC. Brain stimulation techniques could represent a treatment method for post-acute and chronic stages of COVID-19. The first clinical results indicate the therapeutic potential of transcranial direct current stimulation (tDCS) in influencing NP symptoms of PASC. Methods: A four-week, double-blind, randomized, placebo-controlled, parallel study was used to compare the efficacy (response to the treatment, effect duration) and safety of a 4-week active prefrontal cortex (PFC) tDCS (20 tDCS applications with anode placement at F3; 2 mA, 30 min/tDCS session) to placebo-tDCS in the treatment of NP symptoms of PASC. Patients were clinically assessed by “The Fatigue Impact Scale“ (FIS) and “The post-COVID-19 Symptoms Assessment Questionnaire“ (A-PASC), at baseline and at the end of the treatment. Results: Currently, 28 of 34 enrolled patients were included in the Intention-to-treat (ITT) analysis. The treatment groups did not differ in age, gender, and at baseline FIS and A-PASC. PFC-tDCS did not improve (as assessed by FIS and A-PASC) in comparison to sham tDCS at the end of the treatment. However, the study is still in progress and the results will be updated and presented during the oral communication. References: Carfì A., et al. (2020). Persistent symptoms in patients after acute COVID-19. Jama; 324:603–605. Pilloni G., et al. (2020). Update on the use of transcranial electrical brain stimulation to manage acute and chronic COVID-19 symptoms. Front Hum Neurosci. 14:595567. SOBOTA / 4. listopadu 2023 / 9.00–10.30 hod. / SÁLY A + B 20. ČESKO-SLOVENSKÝ PSYCHIATRICKÝ SJEZD 2.–4. 11. 2023 / BRNO ABSTRAKTA
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