IHSS&IWA26 / BRNO / CZECHIA / 23–28 August 2026 BOOK OF ABSTRACTS 10 KL Deciphering the Molecular Composition of Biological NOM and Its Transformation During Disinfection Using a Novel MS-Based Approach Pei Guo, Yufei Chen, Rong Liu, Guangrong Sun, Wei Wang1 1 College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China The extensive utilization of a variety of impaired water supplies in recent years has substantially increased the proportion of biological NOM in source water, which include biomolecules originating from cells, tissues, excreta, and detritus from microbes, plants, and animals at relatively early stages of decomposition. Among them, nucleic acids, which serve as essential, ubiquitous genetic substances across almost all living organisms, enter source waters through natural cell lysis as well as external inputs from agricultural runoff, discharge from livestock husbandry, industrial wastewater, and urban sewage. However, the molecular composition, structural diversity, and transformation pathways of nucleic acids remain poorly understood due to its extreme complexity and the limitations of conventional analytical approaches. In this study, we developed a novel mass spectrometry (MS)-based approach integrating advanced molecular characterization and computational analysis to decipher the molecular composition of biological NOM and track its transformation during disinfection.
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