IHSS&IWA26 / BRNO / CZECHIA / 23–28 August 2026 BOOK OF ABSTRACTS 182 Poster Session / Analysis and Characterization Hall A P1.3 Interactions Between Fulvic Acids and Model Pharmaceuticals Using Isothermal Titration Calorimetry Jitka Krouská1, Kateřina Roušarová1 1 Faculty of Chemistry, Brno University of Technology, Purkynova 464/118, 61200 Brno, Czech Republic, krouska@fch.vut.cz The usage of pharmaceuticals increases worldwide every year. The residues of these substances are excreted by human or animal bodies and thus come into direct contact with the environment, mainly soil and ground water. The accumulation of pharmaceuticals in natural ecosystems may be problematic in the future therefore the knowledge of their behavior, transport and interactions in the ecosystems is essential for their treatment. The most reactive substances in soil are humic as well as fulvic substances [1]. Two fulvic acids stand as the model reactants with different pharmaceuticals in this study. These reactive compounds contain several kinds of active functional groups, such as hydrophilic hydroxylic or carboxylic groups, and diverse hydrophobic structures. The interactions between fulvic acids and solutions of pure drugs were studied by isothermal titration calorimetry. The aim of the study was to observe the heat effects of the interactions and to describe the intensity of the binding process which was influenced also by the presence of metal cations at different concentrations. References 1. M. Klučáková, J. Krouská, Processes 13 (2025), 49.
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